Abstract
Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12–26 days) and long (7–12 days) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spine was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).
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