Spindle cell neoplasm harboring MAPK signaling pathway gene translocation from the spectrum of <i>NTRK</i>-rearranged spindle cell tumor

Abstract

Definition of novel nosological entities based on specific genetic aberrations is becoming more common tendency regarding neoplasms of all sites. Diagnostic approach to such entity represents an urgent issue of modern oncopathology due to the importance of further accurate genetic examination. NTRK-rearranged spindle cell neoplasm is one of such categories and includes a broad spectrum of entities with similar morphology and immunophenotype. Due to the recognition of a variety of related genes and their anomalies, as well as overlapping pathomorphological criteria, the diagnosis NTRK-rearranged spindle cell neoplasia may be an outstanding issue. Based on the clinical case, a possible algorithm of diagnostic approach to this entity is suggested in this article. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.