Spindle Cell Lymphoma of the Oral Cavity: A Case Report and Review of the Literature

Abstract

s t r Prominent spindle cell or sarcomatoid morphology is an infrequent finding in lymphomas. Anaplastic large cell lymphoma with the Tor null-cell phenotype is the most common type of lymphoma to exhibit sarcomatoid features. However, spindle cell variants of B-cell lymphomas have rarely been reported. Many such cases have been described as cutaneous spindle cell B-cell lymphomas, which typically present as solitary or clustered skin nodules with a predilection for the skin of the head, neck, and back. The origin of spindle cell B-cell ymphomas is uncertain, with previous investigators faoring classification as a variant of follicular lymphoma r diffuse large B-cell lymphoma. The present report describes the first well-documented case of spindle cell B-cell lymphoma arising within the oral cavity. In addition, the literature is reviewed for spindle cell B-cell lymphomas involving the head and neck region, in addition to other sites.