Abstract
Spindle cell hemangioma (SCH) is a rare benign vascular tumor and we report 2 cases of SCH who are 50-year-old man and 16-year-old girl. A growing amount of evidence indicates that multifunctional ECM molecule decorin regulate endothelial cell-matrix interactions during angiogenesis. Furthermore, a current publication shows that no detectable decorin expression was found in the stromas of tumor nests in Kaposi’s sarcoma or angiosarcoma groups while the expression was clearly observed in the connective tissue stromas within benign vascular tumors. SCH exhibits spindle cell proliferation and resembles Kaposi’s sarcoma. Therefore, this study examined decorin expression in the tissues of our SCH cases by immunohistochemical analysis. The results demonstrated that immunoreactivity of decorin was clearly detectable in the connective tissue stroma within tumor nests. SCH was first perceived as sarcoma because of spindle cell proliferation, but this proliferation was subsequently found to be reactive. The presence of decorin expression in our cases also indicates that SCH have benign properties. Moreover, this study further increases the reliability of examination of decorin expression for differentiation between benign and malignant vascular tumors.
Highlights
Spindle cell hemangioma (SCH) is rare subcutaneous growth presumably derived from malformed vasculature that was first described by Weiss and Enzinger in 1986
A current publication shows that no detectable decorin expression was found in the stromas of tumor nests in Kaposi’s sarcoma or angiosarcoma groups while the expression was clearly observed in the connective tissue stromas within benign vascular tumors
The results demonstrated that immunoreactivity of decorin was clearly detectable in the connective tissue stroma within tumor nests
Summary
Spindle cell hemangioma (SCH) is rare subcutaneous growth presumably derived from malformed vasculature that was first described by Weiss and Enzinger in 1986. SCH is known as hemangioendothelioma which affects a wide age range and mostly occurs at distal extremities. SCH was initially believed to be a low-grade angiosarcoma, since proliferation of Kaposi’s sarcoma-like spindle cells was detected histologically [1]. Several studies have revealed that the lesion is not a neoplasm possessing metastatic potential, but a reactive cellular proliferation [2]. The proteoglycan decorin was demonstrated to play a key role in angiogenesis in normal and tumor-associated endothelium [3,4,5]. We measured decorin expression immnohistochemically in 2 SCH cases and examine feasibility of decorin stating for distinguishing between SCH and malignant vascular tumors
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Cosmetics, Dermatological Sciences and Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
