Abstract
Spindle cell carcinoma (SpCC), also known as sarcomatoid carcinoma, is a rare biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. An aggressive variant of squamous cell carcinoma, SpCC has spindled or pleomorphic tumor cells, which simulate a sarcoma but are of epithelial origin. It often recurs and metastasizes, underscoring the importance of diagnosing it correctly. A 21-year-old male presented with an irregular painless mass in the anterior mandible. Panoramic radiography and computed tomography showed destructive osteolytic lesion of the mandibular bone. Histopathological analysis revealed pleomorphic spindle cells, with atypical mitoses, arranged in an irregular fascicular pattern, together with small areas of squamous cell carcinoma. The immunohistochemical analysis showed positivity for 34βE12, AE1/AE3, vimentin, and Ki-67. The patient underwent chemotherapy and radiotherapy, which, however, were ineffective. The lesion was deemed inoperable. Currently, the patient has been followed-up via palliative treatment.
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