Abstract
In acute spinal cats treated with monoamine oxidase inhibitors (MAOI's), imipramine facilitated the monosynaptic reflex recorded in the lumbar region. The drug-drug interaction was abolished by chronic thoracic transection, a procedure which reduces markedly lumbosacral norepinephrine and 5-hydroxytryptamine. The MAOI's caused an increase in lumbosacral 5-hydroxytryptamine of about 0.4 μg/g tissue, whereas norepinephrine was unchanged.
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