Abstract
In the current study, a potential treatment modality for spinal cord injury repair was developed. The delivery system was prepared by crushing the Bellis perennis extract-loaded gelatin nanofibers and loading them into calcium alginate hydrogels. The properties of this delivery system including its microarchitecture, biocompatibility, biodegradation, and hemocompatibility were studied in vitro. Then, the healing potential of this system co-administrated with Schwan cells was investigated in a rat model of spinal cord injury. Results showed that co-delivery of Schwan cells and Bellis perennis extract had the highest rate of motor function recovery. Gene expression studies showed that the co-delivery system augmented the tissue expression levels of basic fibroblast growth factor and brain derived neurotrophic factor genes.
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