Abstract
In a previous communication1 a simple method for producing spinal anesthesia in the frog was described. In addition, a series of 10 local anesthetics were studied in summer frogs, kept at temperatures of from 26° to 29°C. The data obtained on each drug included the determination of the minimal anesthetic dose, minimal lethal dose, duration of anesthesia produced by a sublethal dose, and the calculation of a therapeutic coefficient from the fraction M.L.D./M.A.D. Comparatively, this coefficient gives evidence of the usable therapeutic range for each local anesthetic.In this paper similar results are described in which 7 local anesthetics were injected intraspinally into winter frogs kept before, during and after the experiments at 10° to 12°C. This series includes those local anesthetics showing, experimentally, the best possibilities for use in human spinal anesthesia. Five of these drugs had been studied previously in summer frogs, but because of the relatively high temperature prevailing at that time, i...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
