Abstract
For the first time, spin-labelled coumpounds have been obtained by isonitrile-based multi component reactions (IMCRs). The typical IMCR Ugi-protocols offer a simple experimental setup allowing structural variety by which labelled diketopiperazines (DKPs) and peptide-peptoid chimera have been synthesized. The reaction keeps the paramagnetic spin label intact and offers a simple and versatile route to a large variety of new and chemically diverse spin labels.
Highlights
Spin-labelled coumpounds have been obtained by isonitrile-based multi component reactions (IMCRs)
The examples presented here have the spin label on the amine, the carboxylate and the isonitrile building block, the resulting Ugi-products will be transferred to diketopiperazines (DKP) and peptide–peptoid chimera to demonstrate the utility of this approach.[12,13]
To reveal the flexibility of this approach various peptides, peptide–peptoid chimera and diketopiperazines varying the position of the spin-label have been synthesized
Summary
Spin-labelled coumpounds have been obtained by isonitrile-based multi component reactions (IMCRs). The typical IMCR Ugi-protocols offer a simple experimental setup allowing structural variety by which labelled diketopiperazines (DKPs) and peptide–peptoid chimera have been synthesized.
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