Abstract
The Hodgkin–Huxley theory that explains the mechanism of how neurons fire forms the cornerstone of computational neuroscience. But something it hasn't predicted is happening in the brain cortex. Neurons in the brain communicate via electric pulses or action potentials of a fraction of a volt, that last about a thousandth of a second. In 1952, Alan Hodgkin and Andrew Huxley received a share in the Nobel prize for their theory of action potential generation, developed from work on the squid giant axon. Ever since it has been tacitly assumed that nerve impulses are generated in much the same way in all animals from slugs to humans. Now a study of the cortical neurons of higher animals suggests that this assumption may need to be revised. Key features of cortical action potential initiation depart from predictions of the Hodgkin–Huxley theory, as the neurons are much more tailored for fast information processing than was assumed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
