Abstract
Background The amygdaloid nuclear complex (ANC) is a conglomerate of gray matter lying in the depth of the anteromedial temporal lobe ventral to the lentiform nucleus. ANC is critical for producing appropriate emotional and behavioral responses to biologically relevant sensory stimuli. It constitutes an essential link between sensory and limbic areas of the cerebral cortex and subcortical brain regions, such as the hypothalamus, brainstem, and striatum, that are responsible for eliciting emotional and motivational responses. The connectome of the rat ANC is modeled in neuroVIISAS (a platform for mapping, visualization and analysis of connectivity data from tracing studies) that is used to generate realistic large scale networks of all regions of the central nervous system. The models are transferred by a PyNEST interface to the simulation engine NEST and simulation results can be analyzed and visualized by neuroVIISAS.
Highlights
The amygdaloid nuclear complex (ANC) is a conglomerate of gray matter lying in the depth of the anteromedial temporal lobe ventral to the lentiform nucleus
700 Stereotactic tracing studies have been evaluated with regard to connection sources, targets and weights to obtain a directed graph with weights of the ANC and further regions of the central nervous system (CNS) of the rat. neuroVIISAS is developed in JAVA using the Java Development Kit (JDK) (v1.6.0) and the development environment Eclipse (v3.2)
So far, the connectome of the bilateral rat CNS consists of 6690 regions and 39310 connections. 274 connections of 91 subregions of the ANC are found in 700 stereotactic tracing studies
Summary
The amygdaloid nuclear complex (ANC) is a conglomerate of gray matter lying in the depth of the anteromedial temporal lobe ventral to the lentiform nucleus. ANC is critical for producing appropriate emotional and behavioral responses to biologically relevant sensory stimuli. It constitutes an essential link between sensory and limbic areas of the cerebral cortex and subcortical brain regions, such as the hypothalamus, brainstem, and striatum, that are responsible for eliciting emotional and motivational responses. The connectome of the rat ANC is modeled in neuroVIISAS (a platform for mapping, visualization and analysis of connectivity data from tracing studies) that is used to generate realistic large scale networks of all regions of the central nervous system. The models are transferred by a PyNEST interface to the simulation engine NEST and simulation results can be analyzed and visualized by neuroVIISAS
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