Sphingosomes: A Novel Vesicular Drug Delivery System

Abstract

Sphingosomes are bilayer vesicles, primarily made of natural or synthetic sphingolipids, that completely surround an aqueous volume. Sphingosomes address the main issues with vesicle systems (liposomes, niosomes), including their lack of stability, short in vivo circulation times, and poor tumour loading efficacy in cancer therapy. Sphingosomes are a promising vesicular drug delivery system that can transport therapeutic chemicals for a variety of potential applications, according to the review's findings. The development of novel medication delivery systems has received a lot of attention in recent decades (NDDS). To begin, it should administer the medication at a pace determined by the body's requirements throughout the course of therapy. Second, it must direct the active entity to the action location. None of these can be met by conventional-dose forms, including extended-release dosage forms. No existing drug delivery system now acts optimally, although genuine efforts have been made to accomplish them via different new drug delivery methods.1-5