Abstract
Abstract Purpose Emerging evidence has indicated that the sphingolipid sphingosine is involved in cellular differentiation, cell growth, and apoptosis. Here, we elucidated the sphingosine signaling pathways underlying apoptosis and cell growth inhibition. Study section and results Sphingosine induced mitochondria-mediated apoptosis in rat hippocampal neurons and astrocytes by activating caspase-3/-9 via the sphingosine-dependent protein kinase (SDK)/14-3-3 protein/Bax/cytochrome c pathway. This may account for the implication of sphingosine/SDK in the pathogenesis of Alzheimer's disease. Additionally, sphingosine induced apoptosis in MKN-28 human gastric cancer cells in an SDK-dependent manner. In the human malignant pleural mesothelioma cell lines, sphingosine suppressed cell growth by arresting the cell cycle at the G 0 /G 1 phase, along with inhibiting protein kinase Cδ (PKCδ). This suggests that sphingosine/SDK/PKCδ signaling can be potentially used in treating many types of cancers. Conclusion The present review shows that sphingosine induces apoptosis and inhibits the cell cycle by targeting SDK and PKCδ. Our findings represent a fresh insight into sphingosine signaling pathways, and may provide a blueprint for developing drugs for treating Alzheimer's disease and many types of cancers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
