Abstract
Objective: Young women who receive radiotherapy or chemotherapy can suffer irreversible ovarian damage leading to premature ovarian failure. Ovarian tissue obtained prior to such treatment might provide a source of oocytes for in vitro fertilization. However, a reasonable number of oocytes must be matured from the harvested tissue. In an effort to facilitate follicular development and oocyte maturation, our group and others have studied xenotransplants of human ovarian cortex into congenitally immunocompromised murine hosts. Success to date has been limited in part by the onset of follicular atresia and oocyte apoptosis within the first 48 hours of tissue engraftment, presumably before an adequate blood supply has been established. The addition of S1P at supraphysiologic doses has been implicated in the prevention of oocyte death in animal studies of radiation-induced apoptosis. We wanted to evaluate the efficacy of S1P in preventing early-onset follicular atresia and oocyte apoptosis in human ovarian cortex xenotransplanted into NOD-SCID (non obese diabetic severe combined immunodeficient) mice.
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