Abstract
PURPOSE: High permeability pulmonary edema is a key feature of acute lung injury (ALI) and is worsened by mechanical ventilation. Although ALI represents a significant cause of morbidity and mortality in critically ill patients, specific adjunctive therapies are not well characterized. As sphingosine-1-phosphate (Sph-1-P), a biologically active phospholipid, enhances endothelial layer barrier function in vitro, we hypothesized that Sph-1-P would attenuate alveolar edema formation in a canine model of endotoxin (LPS)-induced ALI.
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