Abstract
An established role of sphingosine 1-phosphate receptor-1 in Tcells is to guide their exit from lymph nodes. Reporting in Nature, Mendoza etal. (2017) now show that lymphatic endothelial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondria degradation and thereby support survival of naive Tcells.
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