Abstract
The natural bioactive polysaccharide was regarded as the effective nanocarrier for delivery of active ingredients for its biocompatibility and biodegradability. Moreover, the Fructus Mori polysaccharide has been proved to have good antioxidant and hypoglycemic activities. In this study, the Fructus Mori polysaccharide particles were prepared using antisolvent precipitation method. The bioactive polysaccharide particles exhibited smaller and rounder as the increase of the ethanol/water ratio. The average size, polydispersity index (PDI) and ξ-potential of the bioactive polysaccharide particles were 396.06 nm, 0.38 and −21.23 mV at ethanol/water ratio of 20:1. After spheroidization, the polysaccharide particles exhibited more stable when exposed to heat, increased ionic strength and alkaline conditions. Furthermore, the bioactive polysaccharide particle with the smallest size had the strongest protein adsorption capacity and bioavailability. Especially, the MFP-NP3 showed the ORAC value of 917.06 ± 34.13 μmol TE/g, and the α-glucosidase inhibitory activity of 56.98 ± 1.19% at 0.5 mg/mL. In addition, compared to the native Fructus Mori polysaccharide, the spheroidization enhanced the antioxidant ability and hypoglycemic activity.
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