Abstract
Spherical nucleic acids for precision medicine
Highlights
With the advent of functional cancer genomics, precision medicine has begun to enter clinical practice
To evaluate SNAs as a platform for biotherapeutic gene silencing in cancer, we synthesized SNAs targeted to the oncogene Bcl2-Like12 (Bcl2L12), which is overexpressed in several cancer types, most prominently in Glioblastoma multiforme (GBM), the most aggressive and prevalent manifestation of malignant brain tumors
Analysis of 343 glioma patients in the Repository of Molecular Brain Neoplasia Data (REMBRANDT) identified Bcl2L12 as a potential prognostic factor, as GBM patients with high-level overexpression of Bcl2L12 mRNA have shorter progression-free survival compared to patients with low expression or underexpression of Bcl2L12 (p
Summary
With the advent of functional cancer genomics, precision medicine has begun to enter clinical practice. To evaluate SNAs as a platform for biotherapeutic gene silencing in cancer, we synthesized SNAs targeted to the oncogene Bcl2-Like12 (Bcl2L12), which is overexpressed in several cancer types, most prominently in Glioblastoma multiforme (GBM), the most aggressive and prevalent manifestation of malignant brain tumors. Bcl2L12 is overepxressed in >90% of human primary GBM specimens and exhibits low or undetectable levels in cells of glial origin in the normal brain surrounding tumor tissue or in low-grade astrocytoma [4].
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