Abstract
The success of assisted reproduction technologies in treating human infertility suggests that many causes of infertility can be related to the interaction of spermatozoa with the female reproductive tract. Nonhuman primates are the best model, and may be the only relevant animal model, for human sperm transport and physiology in vivo (1). An understanding of the similarities and differences in gamete biology between primate species is an important step in developing the animal model. In this chapter we highlight our recent work on the physiology of spermatozoa from the laboratory macaque and, in particular, on sperm interaction with the zona pellucida of the oocyte.
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