Abstract
The spermatogenic rebound effect was studied in 5 oligospermic males after testosterone-induced azoospermia. The subjects received 3 weekly doses (50 mcg) of testosterone propionate for 2 1/2 - 4 1/2 months. Seminal fluid analysis was conducted every 6-8 weeks after treatment was terminated. In each case, spermatogenic activity gradually increased after the last treatment until the production of mature spermatozoa exceeded pretreatment levels. A marked improvement was also seen in the posttreatment histologic picture when compared with pretreatment specimens. It is not known whether the rebound response is peculiar to androgenic substances.
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