Sperm Transport Through Vas Deferens: Review of Hypotheses and Suggestions for a Quantitative Model

Abstract

Study of the mechanism of sperm transport through the vas deferens stems from the need to develop acceptable male contraceptive devices or procedures. The object of this paper is to review all the hypothese related to the innervation structure and function of the vas. Also considered are the experimental data and theoretical analyses necessary for understanding seminal fluid transport through the vas. Similarities in structure and function of the ureter are noted. Histologically the vas deferens lumen is bounded by a 3-layer musular wall. The inner and outer layers of smooth muscle wall are arranged longitudinally. The middle layer is circumferential. The vas deferns epididymis prostate and seminal vesicles have only an autonomic nerve suppply via the inferior hypogastric plexus. Studies of the fine details are described as they occur in man and experimental animals. Experiments suggest that the innervation of the vas is seriously damaged by local anesthesia used for vasectomy or reanstamosis when attempted. However the mechanisms of veurotransmission in the vas remain controversial. The various theories of muscular activity of the vas are reviewed. These data may be useful in the design of reversible vas occlusion devices. The improved understanding may suggest simple and effective methods of reversible vasectomy.