Abstract
The effect of the methanolic extract of Alchornea cordifolia leaves on the fertility of senescent male rats was assessed in this study. 40 rats received daily distilled water, testosterone, 200 and 400mg/kg of extract of Alchornea cordifolia. The reproductive organs weight, the gonadotropins, testosterone and cholesterol level, the sperm parameters, histology of the testes and epididymis were assessed. The weight of testes and prostate (400mg/kg) significantly increased (p<0.05) as well as the level of FHS (p<0.001), LH and testosterone (p<0.01) at a dose of 400mg/kg, respectively, while the cholesterol decreased at a dose of 200mg/kg (p<0.05) and 400mg/kg (p<0.01) respectively. The testes and epididymis were full of spermatozoa particularly at a dose of 400mg/kg. The sperm count and morphology significantly increased at both doses of 200mg/kg (p<0.01; p<0.001) and 400mg/kg (p<0.001; p<0.01) respectively. The sperm motion (PROG, VAP, VSL, VCL) (p<0.001), (ALH, BCF) (p<0.05) increased at a dose of 200mg/kg and decreased at a dose of 400mg/ kg. The overall results provide the strong evidence of the fertility potential of the methanolic extract of Alchornea cordifolia leaves in senescent male rats.
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