Abstract
In 2018, we reported changes in preimplantation gene regulation, and defective implantation, in mouse embryos fertilized by intracytoplasmic sperm injection (ICSI) using sperm from the caput epididymis (Conine et al., 2018). We further showed that both the molecular defects and implantation were rescued by microinjection of purified epididymosomal microRNAs, revealing a functional role for sperm-delivered RNAs in the early embryo. At the time, we noted that one of our findings, the inability to recover viable offspring from caput sperm-fertilized embryos (Figure 3 in Conine et al., 2018), contradicted prior studies (Said et al., 2003; Suganuma et al., 2005) which documented successful production of such offspring.
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