Abstract
According to world statistics, 15 % of married couples do not reach pregnancy within one year and seek medical help. At the same time, an important component of the complex problem of infertility, in addition to not getting pregnant, are also pregnancy losses. According to modern ideas, one of the reasons for termination of pregnancy is sperm DNA fragmentation (SDF). According to the European Association of Urology guidelines on male infertility, SDF reduces the chances of natural conception and increases the risk of pregnancy loss. In the European Society of Human Reproduction and Embryology guideline on the management of recurrent pregnancy loss, the definition of SDF is recommended in the algorithm for examining a couple after a single episode of miscarriage. The causes, mechanisms and approaches to correcting increased SDF are the subject of active research; according to PubMed, more than 2,500 papers have been published on this problem to date. Given the huge amount of factual material, the purpose of this review is to highlight the key points of etiology, pathogenesis and approaches to the correction of increased levels of SDF
Highlights
According to the European Association of Urology guidelines on male infertility, sperm DNA fragmentation (SDF) reduces the chances of natural conception and increases the risk of pregnancy loss
In the European Society of Human Reproduction and Embryology guideline on the management of recurrent pregnancy loss, the definition of SDF is recommended in the algorithm for examining a couple after a single episode of miscarriage
The causes, mechanisms and approaches to correcting increased SDF are the subject of active research; according to PubMed, more than 2,500 papers have been published on this problem to date
Summary
Индекс фрагментации ДНК сперматозоидов – необходимость для современной клинической практики. А. Божедомов3 1ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»; Россия, 630117 Новосибирск, ул. 2; 2ООО «Новосибирский центр репродуктивной медицины» ГК «Мать и дитя»; Россия, 630037 Новосибирск, ул. Одна из причин прерывания беременности – повышенный уровень фрагментации ДНК сперматозоидов (ФДС). В руководстве по диагностике и лечению мужского бесплодия Европейской ассоциации урологов указано, что ФДС снижает шансы на зачатие естественным путем и повышает риск невынашивания беременности. В руководстве по лечению привычного невынашивания беременности, разработанном Европейским обществом специалистов по репродукции и эмбриологии человека, рекомендовано определять индекс ФДС в ходе обследования пары после 1 эпизода самопроизвольного прерывания беременности. Ключевые слова: фрагментация ДНК сперматозоидов, индекс фрагментации ДНК сперматозоидов, этиология, патогенез, лечение, выкидыш, раннее невынашивание беременности, мужское бесплодие. А. Индекс фрагментации ДНК сперматозоидов – необходимость для современной клинической практики.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
