Abstract
BackgroundTesticular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm cryopreservation by men with TC from 1990 to 2013 in France.MethodsWe collected data from patients diagnosed with TC who underwent sperm cryopreservation in the French national network of sperm banks. Trends in the incidence of sperm cryopreservation were estimated through two statistical models: the commonly used Poisson regression model and the Verhulst model.ResultsBetween 1990 and 2013, the overall incidence of sperm cryopreservation rose from 1.73 to 5.57 per 100,000 person-years. Poisson regression predicted an incidence of 9 per 100,000 [95% CI = 8.66–9.34] in 2020. However, since 2005, the observed sperm cryopreservation rate seems to be attenuating. The Verhulst model predicted an incidence of 6 per 100,000 after 2020.ConclusionsLimitations include the impossibility of analyzing age-standardized incidence. Based on the Verhulst model, results suggest that it is still relevant to follow up TC incidence and sperm cryopreservation in order to confirm or refute the potential decrease already observed in this disease.
Highlights
Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries
Based on the Verhulst model, results suggest that it is still relevant to follow up TC incidence and sperm cryopreservation in order to confirm or refute the potential decrease already observed in this disease
Sperm cryopreservation incidence in TC confirms a trend toward a slight attenuation or plateau in the TC incidence rate
Summary
Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. Over the past quarter century and in the last decade, the incidence of testicular cancer (TC) has been rising rapidly while at the same time major advances in therapeutic management have led to improved prognoses and survival rates [1,2,3,4]. It is a relatively rare disease which accounts for approximately 1% of all new male cancer cases, TC remains the most frequent cancer in adolescents and young adults in industrialized countries [5,6,7,8]. We recently published the trends for 1973–2007 in sperm cryopreservation for TC throughout this French network, showing an increasing use of sperm banking during this period [12]
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