Abstract
Available experimental and human data show that a number of lifestyle- and environment-related exposures may have negative effects on sperm DNA integrity. The extent of the sperm DNA damage seems to differ between different studies. Such a discrepancy may partly be due to the use of several methods for assessment of sperm DNA integrity, techniques that do not measure exactly the same characteristics of sperm DNA. Another contributing factor may be genetically determined variation in the individual susceptibility. Sperm DNA damage due to environmental and lifestyle factors may have a negative impact on fertility, and there is a potential risk of transmission to the offspring. Therefore, it is of importance to focus on the association between environment and sperm DNA integrity to prevent male subfertility and to avoid potentially serious health effects in the future generation(s).
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