Abstract
Objective: The Sperm Penetration Assay (SPA) evaluates aspects of the ability of human sperm to complete certain processes necessary to achieve fertilization using zona-free hamster oocytes. There is controversy regarding the correlation between the SPA and fertilization of human oocytes or pregnancy outcome. An abnormal SPA is a good predictor of IVF + ICSI pregnancy outcome, but does not affect fertilization rates (Merryman, et al, ASRM abstract #P313, Orlando, FL, 2001). The SCI is the quantitative measurement of the SPA (average number of sperm penetrations per oocyte). Our objective was to determine the SCI score predictive of COH + IUI outcome. Clinical pregnancy per treatment cycle used as the outcome measurement.
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