Speicherung von Mucopolysacchariden und Lipoiden in Tubulusepithelien der Rattenniere nach experimenteller Nierenvenenthrombose

Abstract

The experimental thrombosis of the renal vein of the rat usually leads to renal atrophy. Tubules appearing chromophobic in the light microscope with routine staining methods occur in the cortex of the contracting kidney after the 5th week. They are composed of epithelial cells which contain acid mucopolysaccharides as demonstrated by histochemical reactions. By electron microscopy, numerous membrane bound vacuoles are demonstrable in their cytoplasm; they are either optically empty or show a lamellar composition. The clear regions presumably contained mucopolysaccharides, whereas the elements of the lamellar component are presumably lipoids. These lipoids show frequently a characteristic linear pattern with a period of 5–6 nm. The vacuoles resemble the so-called zebrabodies found in human gangliosidoses and certain mucopolysaccharidoses.