Abstract
Context: Apparently healthy blood donors might carry out transfusion transmitted infections which might be fatal for the donor himself as well as the recipient later on.Aim: To assess the seroprevalence of transfusion-transmitted infections (TTI) among apparently healthy blood donors in Ranchi, India.Methods and Materials: All blood samples were screened for HIV-I and II, HBsAg, HCV (by using third generation enzyme-linked immunoadsorbent assay technique), Syphilis (by Rapid Plasma Reagin Kit), and Malaria antigen both for plasmodium falciparum and plasmodium vivax (by One step, rapid, immunochromatographic test).Result: On screening of 106,306 blood units for TTIs, 1,462 (1.37 %) donors were found positive for one of the TTIs. Highest prevalence was for HBV (970 donors - 0.91%) ranging from 0.73% to 1.19%. This was followed by Malaria (272 donors - 0.25%) ranging from 0.08% to 0.48%, HCV (127 donors - 0.11%) ranging from 0.04% to 0.25%, HIV (72 donors - 0.06%) ranging from 0.03% to 0.10%, and syphilis (21 donors 0.01%) ranging from 0.00% to 0.09%.Conclusions: Apparently healthy blood donors are not omitted from the danger of transfusion-transmitted infection.
Highlights
The goal of any transfusion service is to provide adequate and safe blood and blood products to the recipients
Blood samples were screened for hepatitis B surface antigen (HBsAG) by SD HBsAg Kit (Bio Standard Diagnostic), hepatitis C virus (HCV) antibodies by SD HCV Kit (Bio Standard Diagnostic), and human immunodeficiency virus (HIV-1 & HIV-2) antibodies by Span HIV kit (Span Diagnostic)
Khedmat et al reported the results of serological screening tests for hepatitis B virus (HBV), HCV, HIV, and syphilis infections in Iran performed by Tehran blood transfusion service between 2003 and 2005 in 1,004,889 subjects [13]
Summary
The goal of any transfusion service is to provide adequate and safe blood and blood products to the recipients. With every unit of blood transfusion, there is a 1% chance of transfusion related complications including transfusion-transmitted infections [1]. Blood transfusion departments screen TTI, but they provide information about the prevalence of these infections in populations [6]. More than 18 million units of blood are not screened for transfusion transmissible infections [9]. They are, unlikely to be totally free of the risk of the infections. The aim of our study is to investigate the prevalence of transfusion transmitted infections among apparently healthy donors in Ranchi, India, and to raise the awareness of infectious complications of blood transfusion
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