Abstract
<p><strong>Objective:</strong><strong> </strong>To report our experience with renal biopsy and histopathological pattern of renal disease in a tertiary care hospital in Pakistan over 11 years period.</p><p><strong>Methods:</strong><strong> </strong>All the kidney biopsies performed in our unit from Jan 2001 to Dec 2011 were retrospectively reviewed. We recorded the following data for each patient: name, age, sex, indications for renal biopsy, histopathological diagnosis and lab investigations such as Serum Creatinine, 24 hour urinary protein, urine microscopy, virology (Hbs Ag, Anti HCV) and serology (antids DNA, ANA, C3, C4, C-ANCA and p-ANCA) when indicated. Histopathological examination included Light Microscopy (LM) and Immunofluorescence Microscopy (IF). For LM, six sections were taken and stained with Haemotoxilin and Eosin, and special stains included Periodic acid-Schiff (PAS), Trichome and Grocott’ Smethanamine Silver Stain (GMS). IF study was done using polyclonal antisera against human IgG, IgM, IgA, C3 and Cq. The renal biopsies were performed by a trained Nephrologist.</p><p><strong>Results:</strong><strong> </strong>A total of 329 consecutive percutaneous renal biopsies of native kidneys were reviewed. A total of thirteen specimens were unsatisfactory. Nineteen cases had incomplete data, therefore were excluded. There were 159 males (53.3%) and 138 females (46.46%). Age distribution showed a total no. of 34 (11.44%) of paediatric cases, 238 (80.13%) adult cases and 25 (10.5 %) elderly cases. The most common clinical indication for renal biopsy was unexplained renal failure (n = 116 39%) followed by nephrotic syndrome (n = 83 27.9%). Of the total biopsies included 248 (82.82%) had glomerular disease and 49 (16.49%) had non glomerular disease. The most frequently found primary glomerular lesion was membranous nephropathy (n = 51 17%) followed by focal segmental glomerulosclerosis (n = 26 8.7%). Amongst the non-glomerular lesions, CIN (chronic interstitial nephritis) was the most frequently found lesion (n = 24 8.08%).</p><p><strong>Conclusion: </strong>Membranous Nephropathy followed by Focal Segmental Glomerulosclerosis were the most frequently found renal lesion.</p>
Highlights
Histopathological examination of renal biopsy is a gold standard test for the diagnosis of renal parenchymal disease in patients with renal disease
Renal biopsy data analysis is very important to study the prevalence of biopsy proven renal disease and its Corresponding Author: Dr Naila Asif, Consultant Nephrologist, Department of Nephrology, Liaquat National Hospital and Medical College, Karachi
With increasing incidence of renal disease, it has become very important to timely reach to the diagnosis by understanding the exact nature and pattern of the disease in the region
Summary
Histopathological examination of renal biopsy is a gold standard test for the diagnosis of renal parenchymal disease in patients with renal disease. Renal biopsy data analysis is very important to study the prevalence of biopsy proven renal disease and its Corresponding Author: Dr Naila Asif, Consultant Nephrologist, Department of Nephrology, Liaquat National Hospital and Medical College, Karachi. There is lot of data on epidemiologic population based biopsy proven renal parenchymal diseases with detailed clinicopathologic correlations that could vary according to the country analyzed.[2,3,4]. Studies on the prevalence of renal disease in Pakistan are very scarce.[5,6,7] As many patients come from various regions all over the country, it might be taken as an illustration of the epidemiology of renal disease in our population and can serve as a stimulus for follow up and prospective studies
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
