Spectrum of Histopathological Findings in Liver Biopsy

Abstract

The significance of abnormal liver function tests in the absence of diagnostic serology is unclear. The aim of this prospective study is to report liver biopsy findings in a large group of patients with unexplained abnormal liver biochemistry and correlate them with the clinical features to assess the severity of these diseases. Percutaneous liver biopsy is a relatively safe and accurate method of diagnosing liver disease and should be considered in such cases. A total of 63 liver biopsies were studied for a period of 18 months from june 2012 to december 2013, of which, 34.92% (n=22) hepatic tumors, 20.63.%(13) glycogen storage disorders, 4.7% (n=03) cirrhosis, 4.7% (n=03) fatty liver and 4.7% (n=3) viral hepatitis, 4.7%(3) Non alcoholic steato hepatitis were seen. Further, 01.58% case (n=1) each of extra hepatic biliary atresia, amyloidosis, miliary tuberculosis, liver abscess, and liver cell dysplasia were also observed. Liver biopsy was non specific in 6.34% (n=4) and inadequate in 11.11% (n=7) cases. The role of histopathological examination of liver biopsy is highlighted in this paper.