Abstract
Background - The most common single gene disorders in the world are hemoglobinopathies and thalassaemias. The prevalence of thalassaemias and haemoglobinopathies varies by region. However, some communities have a very high incidence due to consanguinity, caste, and area endogamy, making this group of diseases a major public health problem in our country. High performance liquid chromatography (HPLC) is an automated instrument that is highly sensitive and specic, has a high resolution, and aids in the quantication of various haemoglobins. It is a viable alternative to electrophoresis. the study comp Materials and method - rises of total 220 patients presented with anaemia and were examined in the department of Medicine. Thereafter, blood smaples were taken and the hemoglobin typing were done in the department of Pathology by Cation exchange high performance liquid chromatography. - Among the 220 cases Results majority were females with 64.1% of cases and 35.9% (79) of cases are male. Out of total cases, 119 (54.1%) cases had normal hemoglobin and 101 (45.9%) cases had variant hemoglobin. Out 101 cases of variant hemoglobin, 38 (17.3%) cases were diagnosed with Hb E trait, 27 (12.3%) cases were detected with Hb E disease, 18 (8.2%) cases were diagnosed with Hb E-β Thalassemia, 17 (7.7%) cases were diagnosed as βThalassemia trait and 1 (0.5%) case was detected as β-Thalassemia major
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