Abstract
The common deletion mutations of α-globin genes in the Vietnamese population is not well known. Here we report the presence of five deletional mutations of Southeast Asia in the southern region of Vietnam. The – –SEA (NG_000006.1: g.26264_45564del19301) mutation is the most common type of deletion (87.35%), followed by the –α3.7 (rightward) (NG_000006.1: g.34164_37967del3804) deletion (9.64%), –α4.2 (leftward) (AF221717) deletion (2.41%) and – –THAI (NG_000006.1: g.10664_44164del33501) (0.6%) mutation in this region. The – –FIL (NG_000006.1: g.11684_43534del31581) mutation was not detected in this study. This result provided a view of the distribution of common α-globin gene mutations in Vietnam and could serve as a baseline for further investigations into these genetic defects.
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