Spectrum of Chest CT Findings in a Familial Cluster of COVID-19 Infection.

Abstract

HomeRadiology: Cardiothoracic ImagingVol. 2, No. 1 PreviousNext Images in Cardiothoracic ImagingFree AccessPulmonary ImagingSpectrum of Chest CT Findings in a Familial Cluster of COVID-19 InfectionTianzhu Liu*, Peikai Huang*, Hailong Liu, Lesheng Huang, Ming Lei, Wangdong Xu, Xiaolu Hu, Jun Chen, Bo Liu Tianzhu Liu*, Peikai Huang*, Hailong Liu, Lesheng Huang, Ming Lei, Wangdong Xu, Xiaolu Hu, Jun Chen, Bo Liu Author AffiliationsFrom the Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China (T.L., P.H., H.L., L.H., M.L., W.X., X.H., J.C.) and Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, No. 111 Dade Road, Guangzhou, 510000, China (B.L.).Address correspondence to B.L. (e-mail: [email protected]).Tianzhu Liu*Peikai Huang*Hailong LiuLesheng HuangMing LeiWangdong XuXiaolu HuJun ChenBo Liu Published Online:Feb 13 2020https://doi.org/10.1148/ryct.2020200025MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In * The authors contributed equally to this work.On January 29, 2020, a 43-year-old woman presented with a 4-day history of fever, cough, sputum production, and dyspnea. She had a recent history of travel to Wuhan (the center of the COVID-19 outbreak [formerly known as 2019 novel coronavirus]) with her 15-year-old son. Her temperature was 38°C (100.4°F) and she had coarse breath sounds on auscultation. Chest CT showed peripheral multifocal ground-glass opacities (Fig 1a). Her son also presented with prolonged fever (11 days), but without respiratory symptoms. On examination, his temperature was 39°C (102.2°F), and lungs were clear on auscultation. Chest CT showed centrilobular ground-glass nodules in the left lung (Fig 1b). The patient’s 43-year-old husband, who met the definition for a contact person (1), was asymptomatic on screening, but tested positive for COVID-19 on sputum real-time polymerase chain reaction test, as did the son and the wife. His chest CT was unremarkable (Fig1c), and he eventually developed fever on the following day.Figure 1a: (a) Unenhanced CT image in a 43-year-old woman shows multiple ill-defined ground-glass opacities in the lateral segment of right lower lobe and the posterior segment of left lower lobe. (b) Unenhanced CT image in a 15-year-old male patient shows subtle nodular ground-glass opacities in the posterior segment of left lower lobe. (c) Unenhanced CT image in a 43-year-old man shows normal lungs.Figure 1a:Download as PowerPointOpen in Image Viewer Figure 1b: (a) Unenhanced CT image in a 43-year-old woman shows multiple ill-defined ground-glass opacities in the lateral segment of right lower lobe and the posterior segment of left lower lobe. (b) Unenhanced CT image in a 15-year-old male patient shows subtle nodular ground-glass opacities in the posterior segment of left lower lobe. (c) Unenhanced CT image in a 43-year-old man shows normal lungs.Figure 1b:Download as PowerPointOpen in Image Viewer Figure 1c: (a) Unenhanced CT image in a 43-year-old woman shows multiple ill-defined ground-glass opacities in the lateral segment of right lower lobe and the posterior segment of left lower lobe. (b) Unenhanced CT image in a 15-year-old male patient shows subtle nodular ground-glass opacities in the posterior segment of left lower lobe. (c) Unenhanced CT image in a 43-year-old man shows normal lungs.Figure 1c:Download as PowerPointOpen in Image Viewer This familial cluster exemplifies the spectrum of clinical and radiologic presentation that can be encountered in those infected by COVID-19 (2, 3). This heterogeneity should be a focus for future investigations looking into susceptibilities related to the individual’s immune response and the stage of disease.Disclosures of Conflicts of Interest: T.L. disclosed no relevant relationships. P.H. disclosed no relevant relationships. H.L. disclosed no relevant relationships. L.H. disclosed no relevant relationships. M.L. disclosed no relevant relationships. W.X. disclosed no relevant relationships. X.H. disclosed no relevant relationships. J.C. disclosed no relevant relationships. B.L. disclosed no relevant relationships.* The authors contributed equally to this work.Keywords: Adults, Breast, CT, Infection, Inflammation Authors declared no funding for this work.