Abstract

 
 
 
 Purpose: To study the active ingredients of Chuanxiong (CX) in promoting blood circulation and removing blood stasis.
 Methods: Blood-activating effects and serum HPLC fingerprints of CX extracts from different parts of China were studied and the spectrum-effect relationship between them was established by grey correlation analysis.
 Results: After treatment with CX extracted using different solvents, hemorheology indices were lower than those in the model group, and the effect of dichloromethane was better than that of other solvents (p < 0.05 or p < 0.01). There were 6 common peaks by fingerprint analysis. Peaks 1 - 5 were identified as senkyunolide I, senkyunolide H, senkyunolide A, coniferyl ferulate and ligustilide, respectively.
 Conclusion: Analysis of the spectrum–effect relationship indicates the contribution of the five components to the blood-activating effect of CX. The findings lend some scientific justification for using CX to remove blood stasis, and selection of quality evaluation indices for CX.
 
 
 
Highlights
Chuanxiong (CX) is the dried rhizome of Ligusticum chuanxiong Hort
Compared with the blank group, the hemorheology indices we assessed in the test groups were increased, which suggested that the iced water-induced coagulation model had been created successfully
We revealed that the contributions of six common peaks to the bloodcirculation activity of CX extracts were in the order: peak 1 > peak 5 > peak 3 > peak 4 > peak 2 > peak 6
Summary
CX is a well-known plant used in traditional Chinese medicine (TCM) formulations which activates the blood circulation and relieves pain [1]. It is employed with Angelica sinensis radix and Salvia miltiorrhiza for the treatment of irregular menstruation, migraine, coronary heart disease, and angina [2,3,4]. The main chemical components of CX are volatile oils, alkaloids, organic acids and phenols. Studies [5,6,7] have shown that the main components in the plasma of rats after CX
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