Abstract
BackgroundNeonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in developing countries. Its causative bacteria and their respective sensitivity patterns are different in each hospital and region. The objective of this study was to determine the causative bacteria and their antibiotics sensitivity patterns at the neonatal unit.MethodsThis prospective study was carried out at the Neonatology Unit of Kharadar General Hospital (KGH) from January 2017 to Jun 2019. A total of 162 neonates with suspected sepsis and positive blood cultures were included in the study. Blood culture was done by standard microbiological techniques (BACTEC Method). Continuous data were presented as mean and standard deviation, while categorical data were presented in frequency and percentages.ResultOut of a total of 162 neonates with blood culture positive neonatal sepsis, males were 106 (65.4%). Gram-positive and Gram-negative bacteria were found with a frequency of 83 (51.5%) and 79 (48.5%), respectively. Staphylococcus aureus and Pseudomonas were the commonest isolates in 50.5% and 25.7% of cases, respectively. The Gram-positive organism was mostly sensitive to amikacin and vancomycin whereas the Gram-negative was mostly sensitive to amikacin, imipenem, meropenem, and ciprofloxacin.ConclusionStaphylococcus aureus was the most common bacteria isolated. For the sepsis, the causative bacteria and antibiotics sensitivity pattern changes over a period of time. Continued surveillance is required to help reduce morbidity and mortality through developing institution-based guidelines.
Highlights
Neonatal sepsis is defined as bacteremia and clinical symptoms caused by micro-organisms and their toxic products [1]
Gram-negative organisms like Escherichia coli and Klebsiella have been found to be the leading cause of neonatal infections followed by Gram-positive organisms including Staphylococcus aureus, Group B Streptococcus (GBS), and Staphylococcus epidermidis [8,9,10]
A total of 162 neonates of either gender admitted in the neonatal unit through paediatric OPD/emergency room who presented with sepsis and their blood cultures were found to be positive were included in the study
Summary
Neonatal sepsis is defined as bacteremia and clinical symptoms caused by micro-organisms and their toxic products [1]. Gram-negative organisms like Escherichia coli and Klebsiella have been found to be the leading cause of neonatal infections followed by Gram-positive organisms including Staphylococcus aureus, Group B Streptococcus (GBS), and Staphylococcus epidermidis [8,9,10]. In developed countries, Group B Streptococcus, followed by Escherichia coli, Staphylococcus aureus, Coagulase-negative staphylococcus (CoNS), Listeria monocytogenes, Klebsiella spp., Enterococcus spp., and Pseudomonas aeruginosa are causative organisms of neonatal sepsis [11,12,13]. The objective of this study was to determine the causative bacteria and their antibiotics sensitivity patterns at the neonatal unit
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