Abstract
(−)-Cytisine and its derivatives, characterized by high affinity to neuronal nicotinic acetylcholine receptors (nAChRs), have been shown to be important probes in the research of central nervous system disorders. In this work new halogenated N-benzylcytisine derivatives were obtained, and structurally characterized by NMR spectra and X-ray diffraction. Electron impact mass spectral (EIMS) fragmentations have been investigated and detailed fragmentation pathways have been proposed for all significant ions. For the first time it is shown that cytisine derivatives, under in vitro condition, exhibit promising antiproliferative activities against selected cell lines (A549, MV4-11, NCI-H358, MDA-MB-231, MCF-7, LoVo, HT-29, SK-N-MC). They exhibit lower cytotoxicity against normal murine fibroblasts then cisplatin, the commonly used anticancer drug. N-(4-iodobenzyl)cytisine revealed the strongest antiproliferative activity against lung (NCI-H358) and neuroepithelioma (SK-N-MC; IC50 below 10 μM) cancer cell lines among all compounds studied.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
