Abstract
There are very few studies dealing with the fundamentals of anti-solvent crystallization, even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent, effectively reducing the solubility of the solute in the solvent, and thus, causing the crystallization of the solute. Unfortunately, many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore, the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.
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