Abstract
AbstractKinetics and mechanism of oxidation of levofloxacin (LF) by hexacyanoferrate(III) in aqueous alkaline medium at constant ionic strength of 1.10 mol dm−3 is studied spectrophotometrically. The reaction exhibits, 2:1, [Fe(CN)6]3−:levofloxacin, stoichiometry. The main products identified are 9-fluoro-2,3- dihydro-6-hydroxy-3-methyl-10-(4-methylpiperazin-1-yl)–[1,4]oxazino[2,3,4-ij]quinolin-7-one and [Fe(CN)6]4− were isolated and identified with the help of TLC and characterized by FT-IR and GCMS. The reaction is first order in hexacyanoferrate(III) concentration but fractional order in both levofloxacin and alkali concentrations. Decrease in the dielectric constant of the medium results in a decrease in the rate of reaction. The effects of added products and ionic strength have also been investigated. A mechanism involving free radicals is proposed. In a composite equilibrium step, levofloxacin binds to hexacyanoferrate(III) to form a complex that subsequently decomposes to the products. Investigatio...
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