Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix

Antonina Naumenko,Nataliya Kutsevol,Ehsan N Zare

doi:10.1155/2021/8842052

Abstract

Chlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studied for application during photodynamic therapy. In this work, based on the electron optical absorption spectra, the interaction of photosensitizer molecules with branched star-like copolymer dextran-graft-polyacrylamide in anionic form was investigated and the possibility of using the latter as a carrier for drug delivery to tumor cells was suggested.

Highlights

Photodynamic therapy (PDT) is an advanced method of treating cancer and various benign diseases, including infections [1]
The aim of this work was the comparative investigation of the absorption and fluorescence spectra of Chlorin e6, dimethyl ether of Chlorin e6, and trimethyl ether of Chlorin e6 (Ce6, DME Ce6, and TME Ce6, respectively) both in aqueous solutions and in water solution of branched polymer dextran-graft-polyacrylamide
Comparison of the absorption and fluorescence spectra of solutions of Ce6 in water and in the presence of polymers dextranpolyacrylamide in anionic form showed a visible effect of the anionic matrix on the photophysical properties of studied photosensitizers

Summary

Introduction

Photodynamic therapy (PDT) is an advanced method of treating cancer and various benign diseases, including infections [1]. PDT has a number of advantages over conventional methods of cancer treatment. The low solubility of Chlorin e6 and its derivatives in water forces them to look for special carriers for their address delivery. Our previous study has shown that branched star-like copolymer dextran-graftpolyacrylamide in anionic form could be efficient nanocarriers for drug delivery to tumor cells [7]) and can be efficient matrices for in situ synthesis of gold nanoparticles [8]. The theoretical [9,10,11] and experimental [12, 13] studies of starlike polymers proved that branched macromolecules have a higher local concentration of functional groups capable of binding drugs or other substances causing its incorporation into polymer nanocarriers

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Conclusion