Abstract
Spectroscopic trace-level detections (as low as 1 × 10−11 M) of procaine using surface-enhanced Raman scattering (SERS) technique and utilizing silver nanoparticle (Ag-Np) substrates were successfully accomplished. Significant intensity enhancements of the Raman bands associated with CO stretching, CN stretching and NH2 bending vibrations were observed. Possible modes of SERS interaction between the procaine molecule and Ag-Np were investigated theoretically, and the results were found consistent with experimental data. The intensities of SERS band at 1607 cm−1 were successfully correlated with the concentrations of procaine solutions. The present approach exhibits a high sensitivity and low limit of detection.
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