Abstract
Complexes of Ru(III), Pt(IV), and Au(III) with sulfamethoxazole (SMX) were experimentally produced. The resulted formations of novel metal complexes were discussed using several techniques, such as effective magnetic moment molar conductivity, IR, UV, and 1H NMR spectra, elemental analyses, thermal analysis, microscopic and XRD analyses. The X-ray diffraction patterns of the solid powders of the synthesized sulfamethoxazole complexes indicated their identical formulation. The surface uniformity of the complexes’ samples was confirmed by SEM images. These complexes appear as spots, dark in appearance, with particle sizes of 100–200 nanometers in transmission electron microscopy (TEM) pictures. The sulfamethoxazole ligand was shown to be bidentate coordinated to the metallic ions with sulfonyle oxygen and amido nitrogen groups, according to IR spectral data. Both Ru(III) and Au(III) complexes have an electrolytic nature, but the Pt(IV) complex has non-electrolytic properties. TG and DTG experiments proved the assigned composition and provided information regarding the thermal stability of complexes in a dynamic air atmosphere, according to the thermal analysis. The effect of the novel prepared complexes was examined for antibacterial and antifungal activity in vitro against a variety of pathogens, and they exceeded the sulfamethoxazole ligand in antibacterial activity. It was observed that the Pt(IV) complex has the ultimate activity versus all the assessed organisms relative to all compounds.
Highlights
Sulfamethoxazole (SMX) (4-Amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide) is a sulfonamide bacteriostatic antibiotic most commonly used in a 5:1 synergistic combination with trimethoprim in co-trimoxazole, known by commercial names, such as Bactrim, Septrin, or Septra; in Eastern Europe, it is known as Biseptol
The antimicrobial and antibacterial activities of sulfonamides in association with heavy metals have enhanced their importance in the field of sulfonamide metal complexes [3]
The dishes were kept at room temperature for 1 h before being incubated at 37 ◦C for 24 h
Summary
Sulfamethoxazole (SMX) (4-Amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide) is a sulfonamide bacteriostatic antibiotic most commonly used in a 5:1 synergistic combination with trimethoprim in co-trimoxazole, known by commercial names, such as Bactrim, Septrin, or Septra; in Eastern Europe, it is known as Biseptol. Antibiotic sulfamethoxazole (SMX) is used to treat bacterial infections, such as bronchitis, prostatitis, pneumonia, urinary tract infections, middle ear infections and others. It inhibits Gram-positive and Gram-negative bacteria, such as Escherichia coli and Staphylococcus aureus [10]. Sulfamethoxazole (SMX) molecules include donating atoms (O, N, and S) at many locations, allowing them to function as multi-dentate ligands As a result, they can chelate with a variety of metal ions and structural kinds [15]. These results encouraged us to create novel therapeutic transition metal complexes, with Au (III), Pt(IV), Ru(III), and complexes being relevant medically to study the combined antimicrobial activity effect of drug chelation in conjunction with the metal ions. The prepared complexes were structured and analyzed by the following equipment (Table 1)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
