Spectroscopic, biological, and antitumor studies on N-ethyl- and N-propylimidazole platinum(II) complexes

Abstract

Platinum(II) halide complexes with N-ethylimidazole ( N-EtIm) and N-propylimidazole ( N-Proplm) of the Pt(L) 2X 2 and Pt(L) 4X 2 types (X = Cl, Br, I) were prepared and characterized by far infrared spectra, electronic spectra, and conductivity measurements. The inhibitorial activity of some complexes on the Ca,Mg-dependent ATPase and the antitumor studies of the Pt(L) 4Cl 2 derivatives have been investigated. Pt complexes are not inhibitory active in comparison to the same Pd complexes (if c = 10 −4 M). The LD 50 in physiological solution for [Pt( N-EtIm) 4]Cl 2 · 2H 2O and [Pt( N-PropIm) 4]Cl 2 are higher enough with respect to the cis platinum.