Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands

Abstract

A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3–6), [Pt(Et2DT)2(diamine)](7–8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental analysis, conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr. Our interest in these types of complexes are based on the fact that these complexes are known for their promising biological activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2 µM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0 µM.