Spectroscopic and thermal investigations of charge-transfer complexes formed between cefotaxime sodium drug and various acceptors

Abstract

Charge-transfer complexes formed between cefotaxime sodium (CFX) as electron donor with different electron acceptors as iodine (I2), picric acid (HPA), chloranilic acid (H2CA), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and 7,7′,8,8′-tetracyanoquinodimethane (TCNQ) have been studied in the liquid and solid states. The stoichiometries of all complexes were found to be 1: 1 molar ratio between the donor (CFX) and acceptors (I2, HPA, H2CA, DDQ, and TCNQ). Characterizations of the formed CT-complexes were based on elemental analyses, photometric titration measurements, IR, and 1H NMR spectra as well as thermal analyses. The characteristic physical constants (K CT, ɛCT, μ, ΔG, I D, f, E CT) of the formed CT-complexes are shown to be strongly dependent on the type and structure of the electron acceptors. Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities.