Abstract
Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate – Bromide Mixture
Highlights
A novel class of compounds which revolutionized the treatment of diabetes in the recent past is Dipeptidylpeptidase-4 (DPP-4) inhibitors which are widely known as Gliptins
A survey of chemical literature has shown that the drug Teneligliptin is effectively used to treat Type 2 diabetes mellitus[1,2,3,4,5,6,7] (T2DM)
Since not much attention has been given to develop newer analytical UV spectrophotometric methods for the quantitative determination of such an effective and potential anti diabetic drug in the dosage form and in the pharmaceutical formulations form, the author is prompted to take up this study and develop suitable new, rapid, sensitive, precise and accurate method for
Summary
A novel class of compounds which revolutionized the treatment of diabetes in the recent past is Dipeptidylpeptidase-4 (DPP-4) inhibitors which are widely known as Gliptins. The experimental procedure adopted is as follows: 1 ml of Teneligliptin solution (50 μg/ml), 1 ml of 5M HCl, 1 ml of Bromate-Bromide mixture, 1 ml of Methyl Orange(50 μg/ml) is taken in a 10 ml standard flask.
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