Abstract
3-Methyl-2-benzothiazolinone hydrazone (MBTH) reagent in conjunction with various oxidising agents was found to be useful for the determination of eight widely used diuretics in pure and dosage forms. Of the eight diuretics, amiloride HCl, bumetanide and frusemide react with MBTH without any preliminary treatment, whereas the thiazide diuretics (benzthiazide, hydrochlorothiazide, hydroflumethiazide, polythiazide and trichlormethiazide) react only after release of the masked amino group through alkaline hydrolysis. CeIV, FeIII and IO4– were found to be suitable oxidising agents for these procedures. The sensitivity of these methods is superior to that of many previously reported methods. The results compare well with the reference methods for these drugs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
