Spectrophotometric Method Development for Estimation of Aceclofenac in Phosphate Buffer Dissolution Media

Abstract

A simple, rapid and much economic spectrophotometric method in ultraviolet region has been developed for determination of aceclofenac in bulk and in pharmaceutical formulations. Aceclofenac has its absorption maxima at 273.2 nm in phosphate buffer. The linearity was observed in the concentration range 5-40 mcg/ml with correlation coefficient 0.9992. The same method was applied for the estimation of drug in a tablet dosage form and found to be feasible and reproducible. The method is found to be compatible with dissolution media as the UV cutoff for phosphate buffer is less than 200 nm. The proposed method was validated statistically as per ICH guidelines and found to be accurate and reproducible for the routine dissolution testing of aceclofenac in pharmaceutical dosage form