Spectrophotometric Estimation of Metaxalone and Diclofenac Potassium by Multicomponent Analytical Method from Tablet Dosage Form

Abstract

A simple Multicomponent Spectrophotometric method for simultaneous estimation of Metaxalone and Diclofenac Potassium in combined tablet dosage form had been proposed. Considering the absorption spectra of both analytes in the range of 220-350 nm in methanol, the four wavelengths of equal intervals of 40 nm were selected as 350 nm, 310 nm, 270 nm and 230 nm to produce calibration curves of mixture of analytes. The present method used inbuilt application of instrument (Shimadzu Pharm Spec 1700, UV spectrophotometer) to quantify Metaxalone and Diclofence potassium in formulation. The method had been validated in accordance with ICH guidelines for accuracy and precision.