Spectrophotometric Estimation of Carvedilol via Schiff̕ s base Reaction with 4-Hydroxybenzaldehyde

Abstract

Simple, sensitive, precise, and accurate spectrophotometric method was suggested for the estimation of carvedilol (CARVL) as pure, and in it is formulation. The method is based on Schiff base reaction included condensation of CARVL with 4-hydroxybenzaldehyde(4-HBED) and 0.5 ml of concentrated sulphuric acid was added . All parameters that affected the formation of the product have been studied and the optimal was selected. The colored Schiff base product gave maximum absorption at 533 nm. The linearity of the method was obeyed Beer’s law in the concentration range of 0.5 to 5 µg/ ml, with a molar absorptivity of 8.463 ×104 L mol-1 cm-1. The suggested method was applied to the determination of CARVL in Tablet formulations with accepted results of recovery of CARVL from it is drugs without any interfering of the common excipients.